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It's a complex event that we have to prevent. It's mandatory to have an effective prevention over this event because of the acute important (???) might be very severe, but because of the long-term consequences that this condition(?) have on the natural history of the disease.
Transcriber note: There are two segments where I could not understand the speech, sorry!
It's impossible to understand. He sounds Italian, so he could be mispronouncing words or letters, as the first word could be an acronym (NDS?) The second word, I have no idea, he might mean effect. If you gave more context it might be possible to guess.
Sorry, I just saw these comments and realized you already have most of it transcribed. My bad!
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So, it's a complex event that we have to prevent.
It's mandatory to have an effective prevention over this event because
of the acute important ****, that the *** could be very severe,
but because of the long-term consequences that exacerbation
have on the natural history of the disease.